True or False: Schedule I controlled substances have the lowest potential for human abuse.

Schedule I controlled substances are classified as having a high potential for abuse and no accepted medical use in the United States. This classification is established by the Controlled Substances Act, which categorizes drugs based on their medical utility and potential for dependency or abuse.

Examples of Schedule I substances include heroin, LSD, and marijuana (at the federal level as of the 2023 data). The serious restrictions on these substances are indicative of their potential for abuse, meaning they are considered dangerous and not suitable for use outside of rigorous research settings. In stark contrast, lower schedules (like Schedule IV or V) include substances with accepted medical uses that can be prescribed and have a lower potential for abuse.

Thus, the statement is false, as Schedule I substances are recognized for being at the highest end of the abuse potential scale rather than the lowest.