What is the designation for the first generation of transgenic mice?

The designation for the first generation of transgenic mice is F1. In genetics, the designation of generations starts with the parental generation, often referred to as F0. The first generation of offspring resulting from crossing two parental lines is referred to as F1. This convention is important in genetic studies and breeding programs as it establishes clear lineage and allows researchers to track genetic changes and traits in successive generations.

Transgenic mice are typically created by introducing foreign DNA into the F0 generation, but the offspring that express the transgene for the first time would be classified as F1. Subsequent generations would be labeled F2, F3, and so on, according to their filial generation. Understanding this terminology is crucial for anyone involved in genetic research and breeding programs, particularly when discussing the inheritance of traits and the study of gene function.