What is the purpose of humane endpoints in animal research?

The purpose of humane endpoints in animal research is primarily to minimize animal suffering. Humane endpoints refer to specific criteria or signs that are established to determine when an animal in a study should be removed from the experiment or treated to alleviate pain or distress. By implementing these endpoints, researchers ensure that the welfare of the animals is prioritized, leading to more ethical research practices.

This approach not only respects the life and well-being of the animals but also aligns with the principles of the 3Rs—Replacement, Reduction, and Refinement—in animal research. It facilitates the refinement of research protocols to ensure that animals are not subjected to unnecessary pain or suffering and that their use is justifiable. Therefore, establishing humane endpoints is essential for promoting ethical standards in research involving any animal species.